| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-09-16 | New York Giants (12-4) | 29 | Washington Commanders (8-8) | 30 | - | - |
| 2021-09-19 | New Orleans Saints (8-8) | 7 | Carolina Panthers (12-4) | 26 | - | - |
| 2021-09-19 | Cincinnati Bengals (4-11-1) | 17 | Chicago Bears (9-7) | 20 | - | - |
| 2021-09-19 | Houston Texans (8-8) | 21 | Cleveland Browns (4-12) | 31 | - | - |
| 2021-09-19 | Los Angeles Rams () | 27 | Indianapolis Colts (12-4) | 24 | - | - |
| 2021-09-19 | Denver Broncos (8-8) | 23 | Jacksonville Jaguars (5-11) | 13 | - | - |
| 2021-09-19 | Buffalo Bills (7-9) | 35 | Miami Dolphins (11-5) | 0 | - | - |
| 2021-09-19 | New England Patriots (11-5) | 25 | New York Jets (9-7) | 6 | - | - |
| 2021-09-19 | San Francisco 49ers (7-9) | 17 | Philadelphia Eagles (9-6-1) | 11 | - | - |
| 2021-09-19 | Las Vegas Raiders () | 26 | Pittsburgh Steelers (12-4) | 17 | - | - |
| 2021-09-19 | Minnesota Vikings (10-6) | 33 | Arizona Cardinals (9-7) | 34 | - | - |
| 2021-09-19 | Atlanta Falcons (11-5) | 25 | Tampa Bay Buccaneers (9-7) | 48 | - | - |
| 2021-09-19 | Dallas Cowboys (9-7) | 20 | Los Angeles Chargers (8-8) | 17 | - | - |
| 2021-09-19 | Tennessee Titans (13-3) | 33 | Seattle Seahawks (4-12) | 30 | - | - |
| 2021-09-19 | Kansas City Chefs (2-14) | 35 | Baltimore Ravens (11-5) | 36 | - | - |
| 2021-09-20 | Detroit Lions (0-16) | 17 | Green Bay Packers (6-10) | 35 | - | - |
| Totals | 0/0 | 0/0 | ||||
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