| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-10-07 | Los Angeles Rams () | 26 | Seattle Seahawks (7-9) | 17 | - | - |
| 2021-10-10 | New York Jets (8-8) | 20 | Atlanta Falcons (10-6) | 27 | - | - |
| 2021-10-10 | Philadelphia Eagles (8-8) | 21 | Carolina Panthers (6-10) | 18 | - | - |
| 2021-10-10 | Green Bay Packers (15-1) | 25 | Cincinnati Bengals (9-7) | 22 | - | - |
| 2021-10-10 | New England Patriots (13-3) | 25 | Houston Texans (10-6) | 22 | - | - |
| 2021-10-10 | Tennessee Titans (9-7) | 37 | Jacksonville Jaguars (5-11) | 19 | - | - |
| 2021-10-10 | Detroit Lions (10-6) | 17 | Minnesota Vikings (3-13) | 19 | - | - |
| 2021-10-10 | Denver Broncos (8-8) | 19 | Pittsburgh Steelers (12-4) | 27 | - | - |
| 2021-10-10 | Miami Dolphins (6-10) | 17 | Tampa Bay Buccaneers (4-12) | 45 | - | - |
| 2021-10-10 | New Orleans Saints (13-3) | 33 | Washington Commanders (5-11) | 22 | - | - |
| 2021-10-10 | Cleveland Browns (4-12) | 42 | Los Angeles Chargers (8-8) | 47 | - | - |
| 2021-10-10 | Chicago Bears (8-8) | 20 | Las Vegas Raiders () | 9 | - | - |
| 2021-10-10 | San Francisco 49ers (13-3) | 10 | Arizona Cardinals (8-8) | 17 | - | - |
| 2021-10-10 | New York Giants (9-7) | 20 | Dallas Cowboys (8-8) | 44 | - | - |
| 2021-10-10 | Buffalo Bills (6-10) | 38 | Kansas City Chefs (7-9) | 20 | - | - |
| 2021-10-11 | Indianapolis Colts (2-14) | 25 | Baltimore Ravens (12-4) | 31 | - | - |
| Totals | 0/0 | 0/0 | ||||
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