| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-09-09 | Dallas Cowboys (8-8) | 29 | Tampa Bay Buccaneers (4-12) | 31 | Cowboys | 4 |
| 2021-09-12 | Philadelphia Eagles (8-8) | 32 | Atlanta Falcons (10-6) | 6 | Falcons | 5 |
| 2021-09-12 | Pittsburgh Steelers (12-4) | 23 | Buffalo Bills (6-10) | 16 | Bills | 6 |
| 2021-09-12 | New York Jets (8-8) | 14 | Carolina Panthers (6-10) | 19 | Panthers | 7 |
| 2021-09-12 | Minnesota Vikings (3-13) | 24 | Cincinnati Bengals (9-7) | 27 | Bengals | 8 |
| 2021-09-12 | San Francisco 49ers (13-3) | 41 | Detroit Lions (10-6) | 33 | 49ers | 9 |
| 2021-09-12 | Jacksonville Jaguars (5-11) | 21 | Houston Texans (10-6) | 37 | Texans | 3 |
| 2021-09-12 | Seattle Seahawks (7-9) | 28 | Indianapolis Colts (2-14) | 16 | Seahawks | 16 |
| 2021-09-12 | Arizona Cardinals (8-8) | 38 | Tennessee Titans (9-7) | 13 | Titans | 13 |
| 2021-09-12 | Los Angeles Chargers (8-8) | 20 | Washington Commanders (5-11) | 16 | Chargers | 1 |
| 2021-09-12 | Cleveland Browns (4-12) | 29 | Kansas City Chefs (7-9) | 33 | Chefs | 12 |
| 2021-09-12 | Miami Dolphins (6-10) | 17 | New England Patriots (13-3) | 16 | Patriots | 11 |
| 2021-09-12 | Green Bay Packers (15-1) | 3 | New Orleans Saints (13-3) | 38 | Packers | 2 |
| 2021-09-12 | Denver Broncos (8-8) | 27 | New York Giants (9-7) | 13 | Giants | 10 |
| 2021-09-12 | Chicago Bears (8-8) | 14 | Los Angeles Rams () | 34 | Rams | 15 |
| 2021-09-13 | Baltimore Ravens (12-4) | 27 | Las Vegas Raiders () | 33 | Ravens | 14 |
| Totals | 8/16 | 71/136 | ||||
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