| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-26 | Buffalo Bills (6-10) | 30 | New England Patriots (12-4) | 38 | - | - |
| 2010-09-26 | Atlanta Falcons (4-12) | 27 | New Orleans Saints (11-5) | 24 | - | - |
| 2010-09-26 | Detroit Lions (7-9) | 10 | Minnesota Vikings (5-10-1) | 24 | - | - |
| 2010-09-26 | Cleveland Browns (4-12) | 17 | Baltimore Ravens (8-8) | 24 | - | - |
| 2010-09-26 | Dallas Cowboys (8-8) | 27 | Houston Texans (2-14) | 13 | - | - |
| 2010-09-26 | San Francisco 49ers (12-4) | 10 | Kansas City Chefs (11-5) | 31 | - | - |
| 2010-09-26 | Tennessee Titans (7-9) | 29 | New York Giants (7-9) | 10 | - | - |
| 2010-09-26 | Pittsburgh Steelers (8-8) | 38 | Tampa Bay Buccaneers (4-12) | 13 | - | - |
| 2010-09-26 | Cincinnati Bengals (11-5) | 20 | Carolina Panthers (12-4) | 7 | - | - |
| 2010-09-26 | Philadelphia Eagles (10-6) | 28 | Jacksonville Jaguars (4-12) | 3 | - | - |
| 2010-09-26 | Washington Commanders (3-13) | 16 | St. Louis Rams (7-9) | 30 | - | - |
| 2010-09-26 | Oakland Raiders (4-12) | 23 | Arizona Cardinals (10-6) | 24 | - | - |
| 2010-09-26 | Los Angeles Chargers (9-7) | 20 | Seattle Seahawks (13-3) | 27 | - | - |
| 2010-09-26 | Indianapolis Colts (11-5) | 27 | Denver Broncos (13-3) | 13 | - | - |
| 2010-09-26 | New York Jets (8-8) | 31 | Miami Dolphins (8-8) | 23 | - | - |
| 2010-09-27 | Green Bay Packers (8-7-1) | 17 | Chicago Bears (8-8) | 20 | - | - |
| Totals | 0/0 | 0/0 | ||||
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