| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-10-07 | Los Angeles Rams () | 26 | Seattle Seahawks (11-5) | 17 | - | - |
| 2021-10-10 | New York Jets (6-10) | 20 | Atlanta Falcons (13-3) | 27 | - | - |
| 2021-10-10 | Philadelphia Eagles (4-12) | 21 | Carolina Panthers (7-9) | 18 | - | - |
| 2021-10-10 | Green Bay Packers (11-5) | 25 | Cincinnati Bengals (10-6) | 22 | - | - |
| 2021-10-10 | New England Patriots (12-4) | 25 | Houston Texans (12-4) | 22 | - | - |
| 2021-10-10 | Tennessee Titans (6-10) | 37 | Jacksonville Jaguars (2-14) | 19 | - | - |
| 2021-10-10 | Detroit Lions (4-12) | 17 | Minnesota Vikings (10-6) | 19 | - | - |
| 2021-10-10 | Denver Broncos (13-3) | 19 | Pittsburgh Steelers (8-8) | 27 | - | - |
| 2021-10-10 | Miami Dolphins (7-9) | 17 | Tampa Bay Buccaneers (7-9) | 45 | - | - |
| 2021-10-10 | New Orleans Saints (7-9) | 33 | Washington Commanders (10-6) | 22 | - | - |
| 2021-10-10 | Cleveland Browns (5-11) | 42 | Los Angeles Chargers (7-9) | 47 | - | - |
| 2021-10-10 | Chicago Bears (10-6) | 20 | Las Vegas Raiders () | 9 | - | - |
| 2021-10-10 | San Francisco 49ers (11-4-1) | 10 | Arizona Cardinals (5-11) | 17 | - | - |
| 2021-10-10 | New York Giants (9-7) | 20 | Dallas Cowboys (8-8) | 44 | - | - |
| 2021-10-10 | Buffalo Bills (6-10) | 38 | Kansas City Chefs (2-14) | 20 | - | - |
| 2021-10-11 | Indianapolis Colts (11-5) | 25 | Baltimore Ravens (10-6) | 31 | - | - |
| Totals | 0/0 | 0/0 | ||||
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