| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-26 | Buffalo Bills (13-3) | 30 | New England Patriots (8-9) | 38 | - | - |
| 2010-09-26 | Atlanta Falcons (7-10) | 27 | New Orleans Saints (7-10) | 24 | - | - |
| 2010-09-26 | Detroit Lions (9-8) | 10 | Minnesota Vikings (13-4) | 24 | - | - |
| 2010-09-26 | Cleveland Browns (7-10) | 17 | Baltimore Ravens (10-7) | 24 | - | - |
| 2010-09-26 | Dallas Cowboys (12-5) | 27 | Houston Texans (3-13-1) | 13 | - | - |
| 2010-09-26 | San Francisco 49ers (13-4) | 10 | Kansas City Chefs (14-3) | 31 | - | - |
| 2010-09-26 | Tennessee Titans (7-10) | 29 | New York Giants (9-7-1) | 10 | - | - |
| 2010-09-26 | Pittsburgh Steelers (9-8) | 38 | Tampa Bay Buccaneers (8-9) | 13 | - | - |
| 2010-09-26 | Cincinnati Bengals (12-4) | 20 | Carolina Panthers (7-10) | 7 | - | - |
| 2010-09-26 | Philadelphia Eagles (14-3) | 28 | Jacksonville Jaguars (9-8) | 3 | - | - |
| 2010-09-26 | Washington Commanders (8-8-1) | 16 | St. Louis Rams () | 30 | - | - |
| 2010-09-26 | Oakland Raiders () | 23 | Arizona Cardinals (4-13) | 24 | - | - |
| 2010-09-26 | Los Angeles Chargers (10-7) | 20 | Seattle Seahawks (9-8) | 27 | - | - |
| 2010-09-26 | Indianapolis Colts (4-12-1) | 27 | Denver Broncos (5-12) | 13 | - | - |
| 2010-09-26 | New York Jets (7-10) | 31 | Miami Dolphins (9-8) | 23 | - | - |
| 2010-09-27 | Green Bay Packers (8-9) | 17 | Chicago Bears (3-14) | 20 | - | - |
| Totals | 0/0 | 0/0 | ||||
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