| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-09-23 | Carolina Panthers (6-10) | 24 | Houston Texans (10-6) | 9 | - | - |
| 2021-09-26 | Washington Commanders (5-11) | 21 | Buffalo Bills (6-10) | 43 | - | - |
| 2021-09-26 | Chicago Bears (8-8) | 6 | Cleveland Browns (4-12) | 26 | - | - |
| 2021-09-26 | Baltimore Ravens (12-4) | 19 | Detroit Lions (10-6) | 17 | - | - |
| 2021-09-26 | Arizona Cardinals (8-8) | 31 | Jacksonville Jaguars (5-11) | 19 | - | - |
| 2021-09-26 | Los Angeles Chargers (8-8) | 30 | Kansas City Chefs (7-9) | 24 | - | - |
| 2021-09-26 | New Orleans Saints (13-3) | 28 | New England Patriots (13-3) | 13 | - | - |
| 2021-09-26 | Atlanta Falcons (10-6) | 17 | New York Giants (9-7) | 14 | - | - |
| 2021-09-26 | Cincinnati Bengals (9-7) | 24 | Pittsburgh Steelers (12-4) | 10 | - | - |
| 2021-09-26 | Indianapolis Colts (2-14) | 16 | Tennessee Titans (9-7) | 25 | - | - |
| 2021-09-26 | New York Jets (8-8) | 0 | Denver Broncos (8-8) | 26 | - | - |
| 2021-09-26 | Miami Dolphins (6-10) | 28 | Las Vegas Raiders () | 31 | - | - |
| 2021-09-26 | Tampa Bay Buccaneers (4-12) | 24 | Los Angeles Rams () | 34 | - | - |
| 2021-09-26 | Seattle Seahawks (7-9) | 17 | Minnesota Vikings (3-13) | 30 | - | - |
| 2021-09-26 | Green Bay Packers (15-1) | 30 | San Francisco 49ers (13-3) | 28 | - | - |
| 2021-09-27 | Philadelphia Eagles (8-8) | 21 | Dallas Cowboys (8-8) | 41 | - | - |
| Totals | 0/0 | 0/0 | ||||
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