| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-09-23 | Carolina Panthers (5-12) | 24 | Houston Texans (4-13) | 9 | - | - |
| 2021-09-26 | Washington Commanders (7-10) | 21 | Buffalo Bills (11-6) | 43 | - | - |
| 2021-09-26 | Chicago Bears (6-11) | 6 | Cleveland Browns (8-9) | 26 | - | - |
| 2021-09-26 | Baltimore Ravens (8-9) | 19 | Detroit Lions (3-13-1) | 17 | - | - |
| 2021-09-26 | Arizona Cardinals (11-6) | 31 | Jacksonville Jaguars (3-14) | 19 | - | - |
| 2021-09-26 | Los Angeles Chargers (9-8) | 30 | Kansas City Chefs (12-5) | 24 | - | - |
| 2021-09-26 | New Orleans Saints (9-8) | 28 | New England Patriots (10-7) | 13 | - | - |
| 2021-09-26 | Atlanta Falcons (7-10) | 17 | New York Giants (4-13) | 14 | - | - |
| 2021-09-26 | Cincinnati Bengals (10-7) | 24 | Pittsburgh Steelers (9-7-1) | 10 | - | - |
| 2021-09-26 | Indianapolis Colts (9-8) | 16 | Tennessee Titans (12-5) | 25 | - | - |
| 2021-09-26 | New York Jets (4-13) | 0 | Denver Broncos (7-10) | 26 | - | - |
| 2021-09-26 | Miami Dolphins (9-8) | 28 | Las Vegas Raiders (10-7) | 31 | - | - |
| 2021-09-26 | Tampa Bay Buccaneers (13-4) | 24 | Los Angeles Rams (12-5) | 34 | - | - |
| 2021-09-26 | Seattle Seahawks (7-10) | 17 | Minnesota Vikings (8-9) | 30 | - | - |
| 2021-09-26 | Green Bay Packers (13-4) | 30 | San Francisco 49ers (10-7) | 28 | - | - |
| 2021-09-27 | Philadelphia Eagles (9-8) | 21 | Dallas Cowboys (12-5) | 41 | - | - |
| Totals | 0/0 | 0/0 | ||||
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