| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-11-25 | Chicago Bears (10-6) | 16 | Detroit Lions (4-12) | 14 | - | - |
| 2021-11-25 | Las Vegas Raiders () | 36 | Dallas Cowboys (8-8) | 33 | - | - |
| 2021-11-25 | Buffalo Bills (6-10) | 31 | New Orleans Saints (7-9) | 6 | - | - |
| 2021-11-28 | Pittsburgh Steelers (8-8) | 10 | Cincinnati Bengals (10-6) | 41 | - | - |
| 2021-11-28 | New York Jets (6-10) | 21 | Houston Texans (12-4) | 14 | - | - |
| 2021-11-28 | Tampa Bay Buccaneers (7-9) | 38 | Indianapolis Colts (11-5) | 31 | - | - |
| 2021-11-28 | Atlanta Falcons (13-3) | 21 | Jacksonville Jaguars (2-14) | 14 | - | - |
| 2021-11-28 | Carolina Panthers (7-9) | 10 | Miami Dolphins (7-9) | 33 | - | - |
| 2021-11-28 | Tennessee Titans (6-10) | 13 | New England Patriots (12-4) | 36 | - | - |
| 2021-11-28 | Philadelphia Eagles (4-12) | 7 | New York Giants (9-7) | 13 | - | - |
| 2021-11-28 | Los Angeles Chargers (7-9) | 13 | Denver Broncos (13-3) | 28 | - | - |
| 2021-11-28 | Los Angeles Rams () | 28 | Green Bay Packers (11-5) | 36 | - | - |
| 2021-11-28 | Minnesota Vikings (10-6) | 26 | San Francisco 49ers (11-4-1) | 34 | - | - |
| 2021-11-28 | Cleveland Browns (5-11) | 10 | Baltimore Ravens (10-6) | 16 | - | - |
| 2021-11-29 | Seattle Seahawks (11-5) | 15 | Washington Commanders (10-6) | 17 | - | - |
| Totals | 0/0 | 0/0 | ||||
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