| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2010-09-26 | Buffalo Bills (13-4) | 30 | New England Patriots (4-13) | 38 | - | - |
| 2010-09-26 | Atlanta Falcons (8-9) | 27 | New Orleans Saints (5-12) | 24 | - | - |
| 2010-09-26 | Detroit Lions (15-2) | 10 | Minnesota Vikings (14-3) | 24 | - | - |
| 2010-09-26 | Cleveland Browns (3-14) | 17 | Baltimore Ravens (12-5) | 24 | - | - |
| 2010-09-26 | Dallas Cowboys (7-10) | 27 | Houston Texans (10-7) | 13 | - | - |
| 2010-09-26 | San Francisco 49ers (6-11) | 10 | Kansas City Chefs (15-2) | 31 | - | - |
| 2010-09-26 | Tennessee Titans (3-14) | 29 | New York Giants (3-14) | 10 | - | - |
| 2010-09-26 | Pittsburgh Steelers (10-7) | 38 | Tampa Bay Buccaneers (10-7) | 13 | - | - |
| 2010-09-26 | Cincinnati Bengals (9-8) | 20 | Carolina Panthers (5-12) | 7 | - | - |
| 2010-09-26 | Philadelphia Eagles (14-3) | 28 | Jacksonville Jaguars (4-13) | 3 | - | - |
| 2010-09-26 | Washington Commanders (12-5) | 16 | St. Louis Rams () | 30 | - | - |
| 2010-09-26 | Oakland Raiders () | 23 | Arizona Cardinals (8-9) | 24 | - | - |
| 2010-09-26 | Los Angeles Chargers (11-6) | 20 | Seattle Seahawks (10-7) | 27 | - | - |
| 2010-09-26 | Indianapolis Colts (8-9) | 27 | Denver Broncos (10-7) | 13 | - | - |
| 2010-09-26 | New York Jets (5-12) | 31 | Miami Dolphins (8-9) | 23 | - | - |
| 2010-09-27 | Green Bay Packers (11-6) | 17 | Chicago Bears (5-12) | 20 | - | - |
| Totals | 0/0 | 0/0 | ||||
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