| Date | Away | Score | Home | Score | Pick | Confidence |
|---|---|---|---|---|---|---|
| 2021-10-07 | Los Angeles Rams () | 26 | Seattle Seahawks (10-6) | 17 | - | - |
| 2021-10-10 | New York Jets (10-6) | 20 | Atlanta Falcons (8-8) | 27 | - | - |
| 2021-10-10 | Philadelphia Eagles (7-9) | 21 | Carolina Panthers (15-1) | 18 | - | - |
| 2021-10-10 | Green Bay Packers (10-6) | 25 | Cincinnati Bengals (12-4) | 22 | - | - |
| 2021-10-10 | New England Patriots (12-4) | 25 | Houston Texans (9-7) | 22 | - | - |
| 2021-10-10 | Tennessee Titans (3-13) | 37 | Jacksonville Jaguars (5-11) | 19 | - | - |
| 2021-10-10 | Detroit Lions (7-9) | 17 | Minnesota Vikings (11-5) | 19 | - | - |
| 2021-10-10 | Denver Broncos (12-4) | 19 | Pittsburgh Steelers (10-6) | 27 | - | - |
| 2021-10-10 | Miami Dolphins (6-10) | 17 | Tampa Bay Buccaneers (6-10) | 45 | - | - |
| 2021-10-10 | New Orleans Saints (7-9) | 33 | Washington Commanders (9-7) | 22 | - | - |
| 2021-10-10 | Cleveland Browns (3-13) | 42 | Los Angeles Chargers (4-12) | 47 | - | - |
| 2021-10-10 | Chicago Bears (6-10) | 20 | Las Vegas Raiders () | 9 | - | - |
| 2021-10-10 | San Francisco 49ers (5-11) | 10 | Arizona Cardinals (13-3) | 17 | - | - |
| 2021-10-10 | New York Giants (6-10) | 20 | Dallas Cowboys (4-12) | 44 | - | - |
| 2021-10-10 | Buffalo Bills (8-8) | 38 | Kansas City Chefs (11-5) | 20 | - | - |
| 2021-10-11 | Indianapolis Colts (8-8) | 25 | Baltimore Ravens (5-11) | 31 | - | - |
| Totals | 0/0 | 0/0 | ||||
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